Oral formulations of chemical drugs

The research group of Prof. Kuentz is active in the field of oral dosage forms for mostly poorly water-soluble compounds. A focus is given on lipid-based drug delivery systems as well as solid drug dispersions to target enhanced solubilization and absorption. There are different formulation and process technologies available on a laboratory scale, which include among others, vacuum homogenization, micro particle prilling, hot melt extrusion, and spray drying.

New computer-based and analytical methods support a rational formulation design from molecular drug-excipient interactions to the microstructure of the final dosage form. Digital and analytical imaging approaches provide research tools to facilitate a modern version of Quality by Design for oral dosage forms.