NMR is a powerful and establish analytical method, which still relies on mostly manual interpretation of its spectra. While the simulation of NMR spectra is in the meantime quite accurate there is no pendant for the analysis. Such a capability is particularly interesting as it would allow to include NMR…
Alternative RNA splicing is a regulatory cellular mechanism to create multiple mRNA molecules from the same gene and is often disrupted in diseases. We could show in the international Pan-Cancer Analysis of Whole Genomes (PCAWG) study that such disruptions in alternative splicing patterns are widespread in cancer. By developing new…
Microbial communities have been identified as promising key-players for the biodegradation of pharmaceutical micropollutants such as Ibuprofen or Acetaminophen, which are continuously released into various environmental compartments, where they can persist. By using a combinatorial approach of bioinformatics (e.g. amplicon-seq, metagenomics), microbial cultivation and analytics, we are able to identify…
Physicians use their clinical experience to identify patterns (such as symptoms) that are common among a group of patients, leading to treatment strategies. However, rather than having to base judgement on few patients, digital medical information allows the inspection of data from thousands if not Millions of patients at the same time. In…
The progression of multiple sclerosis (MS) is characterized by the evolution of brain lesions. Traditionally, neuroradiologists need to manually track and compare a large number of lesions in MRI images over multiple exams. Novel AI methods support this process, by automating the detection, localization, and quantification of lesions. WebJazz is a web application that makes…
Andrea BiederCell-based in vitro pharmacological assays are routinely used to identify new drug candidates and test drug safety. However, the standard models have limits regarding their physiological relevance. One powerful new tool is the use of organoids – stem-cell derived self-organizing cell assemblies, that mimic closely the physiology of…
The pig is an ideal model for the human digestive tract. Humans and pigs’ guts share anatomical and physiological similarities as well as microbial functionality. Pig feces samples are commonly used as proxy of microbial activity in the colon, while majority of fermentation processes occur in the cecum. In this…
To start the design of an orthosis or of a prosthesis, orthopedists commonly use plaster casting to acquire the patient’s limb shape. The rest of the design workflow is so far already digital. However, the limb shape acquisition is still analog, wet, inaccurate and time consuming. The Swiss startup BellwaldTec…
SuperPro Designer is a digital tool for modeling, evaluating and optimizing various batch and continuous processes in a wide range of industries such as biotechnology, pharmaceuticals, food processing, water purification, wastewater treatment, air pollution control, etc. With your designed model, you can obtain various information such as costs, feasibility, bottlenecks,…