Biology, Medicine

Pathogenic cancer-specific alternative splicing events

26. Januar 2023

Alternative RNA splicing is a regulatory cellular mechanism to create multiple mRNA molecules from the same gene and is often disrupted in diseases. We could show in the international Pan-Cancer Analysis of Whole Genomes (PCAWG) study that such disruptions in alternative splicing patterns are widespread in cancer. By developing new computer algorithms, machine learning models, and databases (www.caniso.net) we aim to further understand the origins and consequences of such alternative splicing disruption and work towards developing new splicing biomarkers for superior diagnostic, treatment, and medication.

Software pipeline behind https://www.caniso.net

Contact

Prof. Dr. Abdullah Kahraman

Expert in Clinical Bioinformatics, Computational Biology, Chemoinformatics, Precision Medicine, Structural Biology, NGS, Interactomics, Proteomics

Schlagworte: cancer, clinics, disease, modelling, omics, precision medicine

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