Andrea BiederCell-based in vitro pharmacological assays are routinely used to identify new drug candidates and test drug safety. However, the standard models have limits regarding their physiological relevance. One powerful new tool is the use of organoids – stem-cell derived self-organizing cell assemblies, that mimic closely the physiology of…

SuperPro Designer is a digital tool for modeling, evaluating and optimizing various batch and continuous processes in a wide range of industries such as biotechnology, pharmaceuticals, food processing, water purification, wastewater treatment, air pollution control, etc. With your designed model, you can obtain various information such as costs, feasibility, bottlenecks,…

The use of many anticancer drugs is problematic due to severe adverse effects. While the recent clinical launch of several kinase inhibitors led to tremendous progress, these targeted agents tend to be of non-specific nature within the kinase target class. A future strategy will be the development of nanocarrier-based systems…

Pharmaceutical technology is like many other applied disciplines greatly affected by the digital revolution in that availability of diverse computational tools change the way how dosage forms are developed and manufactured. The current presentation gives a brief overview followed by several case studies in computational pharmaceutics with a focus on…

Host cell proteins (HCPs) are one of the major process-related impurities of therapeutic protein production based on biological systems such as Chinese hamster ovary (CHO) cells. For clinical application of biopharmaceuticals, the control of HCP is crucial for product stability, product quality and patient safety. This project aims to focus…