Cancer-specific Alternative Splicing Events

Novel diagnostic and prognostic biomarkers for different cancer types CanIso.netA new database to assess the impact of cancer-specific Most Dominant Transcripts (cMDT) using an isoform-specific interaction network. Alternative RNA splicing is a regulatory cellular mechanism to create multiple mRNA molecules from the same gene and is often disrupted in diseases. The Data Science in Life Science Team headed by Dr. Abdullah Kahraman could show in the international Pan-Cancer Analysis of Whole Genomes (PCAWG) study that such disruptions in alternative splicing patterns are widespread in cancer. Based on these results, they have started to search for novel diagnostic and prognostic biomarkers for superior diagnostic, treatment, and medication for cancer patients.Tools and DatabasesTo aid the search the team behind Dr Kahraman is developing different tools and databases related to identifying pathogenic alternative splicing events. These databases include CanIsoNet, a database visualizing protein-protein…