New publication about enzyme immobilization on nanoparticles

Two groups at the FHNW’s Institute for Chemistry and Bioanalytics recently published their collaborative research on Reduction-Responsive Immobilised and Protected Enzymes in the journal RSC Nanoscale Advances.

In this work, enzymes were immobilised onto silica nanoparticles and shielded by an organosilica layer. Under reducing conditions, enzyme activation is triggered while the organosilica shield protects them and prevents their leaching.

The project was led by Dr. Amir Nazemi from the Molecular Nanotechnology group, under the supervision of Dr. Patrick Shahgaldian. Dr. Laura Suter-Dick and Natasha Santocroce from the Cell Biology and In Vitro Toxicology group provided support in assessing the biocompatibility of the nanobiocatalysts on a liver cell line.